Document Type
Article
Version
Final Published Version
Publication Title
Molecules
Volume
28
Publication Date
2023
Abstract
This contribution describes the path of my nearly forty-year quest to understand the special ligand coordinated to molybdenum and tungsten ions in their respective enzymes. Through this quest, I aimed to discover why nature did not simply use a methyl group on the dithiolene that chelates Mo and W but instead chose a complicated pyranopterin. My journey sought answers through the synthesis of model Mo compounds that allowed systematic investigations of the interactions between molybdenum and pterin and molybdenum and pterin-dithiolene and revealed special features of the pyranopterin dithiolene chelate bound to molybdenum.
Citation
Burgmayer, Sharon J. Nieter. 2023. “Making Moco: A Personal History.” Molecules 28 (21): 7296. https://doi.org/ 10.3390/molecules28217296.
DOI
https://doi.org/ 10.3390/molecules28217296
