Document Type
Article
Version
Author's Final Manuscript
Publication Title
Organic Letters
Volume
20
Publication Date
2018
Abstract
A new enantioselective desymmetrizing Mizoroki–Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently synthesized from Birch reduction–alkylation of benzoic acid and benzoate esters.
Citation
Krasley, Andrew T., William P. Malachowski, Hannah M. Terz, and Sabrina Tran Tien. 2018. "Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters." Organic Letters 20.7: 1740–1743. Org. Lett., 2018, 20 (7), pp 1740–1743
DOI
http://doi.org/10.1021/acs.orglett.8b00196
