Author's Final Manuscript
A new enantioselective desymmetrizing Mizoroki–Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently synthesized from Birch reduction–alkylation of benzoic acid and benzoate esters.
Krasley, Andrew T., William P. Malachowski, Hannah M. Terz, and Sabrina Tran Tien. 2018. "Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters." Organic Letters 20.7: 1740–1743. Org. Lett., 2018, 20 (7), pp 1740–1743